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Perit Dial Int 22(1): 27-31 2002
© 2002 International Society for Peritoneal Dialysis
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Peritoneal Dialysis International, Vol 22, Issue 1, 27-31
Copyright © 2002 by International Society for Peritoneal Dialysis

Evaluation Studies

Colonization-resistant antimicrobial-coated peritoneal dialysis catheters: evaluation in a newly developed rat model of persistent Pseudomonas aeruginosa peritonitis

A Finelli, LL Burrows, FA DiCosmo, V DiTizio, S Sinnadurai, DG Oreopoulos, and AE Khoury

Department of Surgery, University of Toronto, Ontario, Canada.

OBJECTIVE: Development of a rat model of persistent peritonitis and evaluation of the ability of liposomal ciprofloxacin hydrogel-coated silicone to resist colonization. DESIGN: A newly developed model of persistent Pseudomonas aeruginosa peritonitis to compare the ability of liposomal ciprofloxacin hydrogel (LCH)-coated silicone versus plain silicone for resistance to bacterial colonization. ANIMALS: Male Sprague-Dawley rats. RESULTS: Inoculating the peritoneum of rats with 1 mL 0.5% agar containing 10(6) colony-forming units (cfu)/mL P. aeruginosa in the presence of a plain silicone coupon resulted in persistent peritonitis for at least 7 days. Plain silicone coupons in all 40 rats were colonized (median 2.54 x 10(3) cfu/cm2; range 5.0 x 10(1)-1.0 x 10(6) cfu/cm2) and peritoneal washings were consistently culture-positive. In contrast, the LCH coupons removed after 7 days from the 40 test rats were sterile, as were the peritoneal washings, and there was no evidence of peritonitis. Blood cultures were negative in both groups. CONCLUSIONS: Liposomal ciprofloxacin hydrogel-coated silicone resists colonization in this rat model of persistent P. aeruginosa peritonitis.




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