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Perit Dial Int 20(Suppl_2): 26-30 2000
© 2000 International Society for Peritoneal Dialysis
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Peritoneal Dialysis International, Vol 20, Issue Suppl_2, S26-S30
Copyright © 2000 by International Society for Peritoneal Dialysis

Articles

Chemistry of glucose and biochemical pathways of biological interest

M Pischetsrieder

Institut fur Pharmazie und Lebensmittelchemie, Friedrich-Alexander-Universitat, Erlangen, Germany.

Glucose degradation, yielding GDPs, can take place in vivo or during heat treatment of glucose solutions. AGEs are formed from the interaction of D-glucose with reactive amino-acid side chains of proteins. Both GDPs and AGEs have been shown to impair cellular function. GDPs have additional damaging effects because they strongly promote AGE formation (as compared to D-glucose).






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