Efficacy of recombinant human erythropoietin administered subcutaneously to CAPD patients once weekly

HOME

HELP

FEEDBACK

SUBSCRIPTIONS

Clinical Trial

Efficacy of recombinant human erythropoietin administered subcutaneously to CAPD patients once weekly

JJ Frifelt, E Tvedegaard, K Bruun, G Steffensen, C Cintin, M Breddam, H Dominguez, and JD Jorgensen

Renal Department, Odense University Hospital, Denmark.

OBJECTIVE: The purpose of the present study was to compare the dosage requirements of recombinant human erythropoletin (rHuEPO) administered subcutaneously (SC) either one or three times weekly. DESIGN: A randomized, prospective study. SETTING: The patients were recruited from two university hospitals and five county hospitals. PATIENTS: Thirty-three anemic patients on continuous ambulatory peritoneal dialysis (CAPD) treatment for end-stage renal failure completed the study. INTERVENTIONS: Initially, all were treated with rHuEPO SC three times a week until hemoglobin blood levels (Hb) remained constant between 105 and 121 g/L for three months. Following randomization, 17 patients continued the same treatment schedule (group A), while 16 patients received the same dose, but administered only once weekly for three months (group B). MAIN OUTCOME MEASURES: The Hb levels and rHuEPO doses at the start and at the end of the three-month study period. RESULTS: In group A the median Hb at randomization was 118 g/L (109-119) (25-75 percentiles) and, after three months, was 113 g/L (106-119) (p = 0.13), while in group B the median Hb was 114 g/L (108-119) and 114 g/L (106-120), respectively (p = 0.50). In group A the weekly dose of rHuEPO remained virtually unchanged during the study period, 65 (55-86) and 66.3 (55-95) U/kg/week, respectively, while in group B it was increased from 60.2 (46-88) to 77 (60-90) U/kg/week. The 22% increase (p = 0.03) took place during the last two weeks. CONCLUSIONS: Our findings indicate that a once-weekly SC dosing regimen of rHuEPO in anemic CAPD patients was equally effective in maintaining a stable hemoglobin level as a thrice-weekly dosing regimen.

This article has been cited by other articles:

W. Grzeszczak, W. Sulowicz, B. Rutkowski, A. F. de Vecchi, R. Scanziani, P.-Y. Durand, A. Bajo, V. Vargemezis, and on behalf of the European Collaborative Group
The efficacy and safety of once-weekly and once-fortnightly subcutaneous epoetin {beta} in peritoneal dialysis patients with chronic renal anaemia
Nephrol. Dial. Transplant., May 1, 2005; 20(5): 936 - 944.
[Abstract] [Full Text] [PDF]

I. C. Macdougall
Once-weekly erythropoietic therapy: is there a difference between the available preparations?
Nephrol. Dial. Transplant., December 1, 2002; 17(12): 2047 - 2051.
[Full Text] [PDF]

L. G. Weiss, N. Clyne, J. D. Fihlho, C. Frisenette-Fich, J. Kurkus, and B. Svensson
The efficacy of once weekly compared with two or three times weekly subcutaneous epoetin {beta}: results from a randomized controlled multicentre trial
Nephrol. Dial. Transplant., December 1, 2000; 15(12): 2014 - 2019.
[Abstract] [Full Text] [PDF]

				I. C. Macdougall Once-weekly erythropoietic therapy: is there a difference between the available preparations? Nephrol. Dial. Transplant., December 1, 2002; 17(12): 2047 - 2051. [Full Text] [PDF]

				L. G. Weiss, N. Clyne, J. D. Fihlho, C. Frisenette-Fich, J. Kurkus, and B. Svensson The efficacy of once weekly compared with two or three times weekly subcutaneous epoetin {beta}: results from a randomized controlled multicentre trial Nephrol. Dial. Transplant., December 1, 2000; 15(12): 2014 - 2019. [Abstract] [Full Text] [PDF]