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Perit Dial Int 15(Suppl_7): 13-22 1995
© 1995 International Society for Peritoneal Dialysis
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Peritoneal Dialysis International, Vol 15, Issue 7_Suppl, S13-S22
Copyright © 1995 by International Society for Peritoneal Dialysis

Articles

The biology of the mesothelium during peritoneal dialysis

JT Hjelle, MA Miller-Hjelle, and JW Dobbie

University of Illinois College of Medicine at Peoria 61729, USA.

Substantial derangements of mesothelial biology are observed during experimental simulations of dialysis conditions, inferred from the content of human dialysis effluent and visualized by microscopy of human mesothelial biopsies. Can osmotically active solutions be made biocompatible with the osmoregulatory system of the mesothelium? Can the contributions of the mesothelium to host defenses against inflammation and/or infection be supported during CAPD? Do underlying metabolic derangements present in various kidney diseases and end-stage renal disease, regardless of cause, require customized CAPD protocols and solutions? Use of dialysis solutions less directly toxic to the mesothelium is a necessary step toward some day manipulating peritoneal biology by pharmacological and therapeutic modalities.






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