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Perit Dial Int 13(Suppl_2): 355-356 1993
© 1993 International Society for Peritoneal Dialysis
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Peritoneal Dialysis International, Vol 13, Issue Suppl_2, S355-S356
Copyright © 1993 by International Society for Peritoneal Dialysis

Articles

Single daily dose of aminoglycosides in the treatment of continuous ambulatory peritoneal dialysis peritonitis

SI Vas

University of Toronto, Toronto Hospital, Toronto Western Division, Ontario, Canada.

Toxicity of aminoglycosides is a major concern in the treatment of continuous ambulatory peritoneal dialysis (CAPD) peritonitis. The relatively high blood levels and prolonged and repeated usage may all be contributory. The recognition of the so-called postantibiotic effect, together with the increased phagocytosis of antibiotic-treated cells, may introduce a new mode of therapy with once-daily dosage. Intermittent therapy with vancomycin is already generally accepted. The extension of this modality to antibiotic therapy is discussed.






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