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Perit Dial Int 13(3): 208-213
1993
© 1993 International Society for Peritoneal Dialysis
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Peritoneal Dialysis International, Vol 13, Issue 3, 208-213
Copyright © 1993 by International Society for Peritoneal Dialysis

Articles

Heat sterilization of fluids for peritoneal dialysis gives rise to aldehydes

CB Nilsson-Thorell, N Muscalu, AH Andren, PT Kjellstrand, and AP Wieslander

Regulatory Affairs and Medical Research, Gambro Lundia AB, Sweden.

OBJECTIVE: To chemically identify and quantify glucose degradation products in heat sterilized fluids for peritoneal dialysis. DESIGN: Three different brands of commercial PD-fluids and one laboratory made fluid, sterilized either by heat or filtration, were investigated for the presence of aldehydes. MEASUREMENTS: Aldehydes were identified and quantified using high performance liquid chromatography and gas chromatography. RESULTS: The tested brands of heat sterilized PD-fluids were found to contain several different aldehydes while the sterile filtered PD-fluid contained none. The highest concentrations in commercial PD-fluids of these aldehydes were: acetaldehyde (420 microns), glyoxal (14 microns), methylglyoxal (12 microns) and formaldehyde (11 microns). Valeraldehyde was also identified but not quantified. The presence of 5-HMF (15 microns) and 2-furaldehyde (2 microns), which has been identified by others, was confirmed. CONCLUSIONS: The heat sterilization of commercial PD-fluids gives rise to several aldehydes which may contribute to adverse effects of PD-fluids on patients.




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